Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea
W. W. Metcalf, D. D. Nayak, N. Mahanta, D. A. Mitchell
The paper identifies thioglycine modification in McrA, a key enzyme in methane metabolism, and shows its role in protein stability rather than catalysis, with implications for evolutionary origins.
bioRxiv · Mar 27, 2017Biochemistry