D. D. Nayak

Physiological and transcriptomic response to methyl-coenzyme M reductase limitation in Methanosarcina acetivorans

This study investigates the physiological and transcriptomic response of Methanosarcina acetivorans to MCR limitation, showing that MCR is not growth rate limiting in substrate-replete cultures but can become limiting under specific conditions.

MmcA is an electron conduit that facilitates both intracellular and extracellular electron transport in Methanosarcina acetivorans

This study identifies MmcA as an electron conduit in Methanosarcina acetivorans that supports both methanogenesis and dissimilatory metal reduction.

McrD binds asymmetrically to methyl-coenzyme M reductase improving active site accessibility during assembly

The paper structurally characterizes intermediate states of methyl-coenzyme M reductase (MCR) assembly, revealing McrD's role in facilitating F430 cofactor installation.

The dual role of a multi-heme cytochrome in methanogenesis: MmcA is important for energy conservation and carbon metabolism in Methanosarcina acetivorans

This study investigates the roles of the Rnf complex and MmcA in Methanosarcina acetivorans, showing MmcA is essential for acetoclastic methanogenesis but not for growth on methylated compounds, and reveals alternative ferredoxin regeneration pathways.

An Archaea-Specific c-type Cytochrome Maturation Machinery is Crucial for Methanogenesis in Methanosarcina acetivorans

This study identifies an Archaea-specific c-type cytochrome maturation machinery essential for methanogenesis in Methanosarcina acetivorans, showing its conservation and substrate-specific roles.

EfgA is a conserved formaldehyde sensor that halts bacterial translation in response to elevated formaldehyde

This study identifies EfgA as a formaldehyde sensor in Methylorubrum extorquens that inhibits translation under formaldehyde stress, without enzymatic detoxification.

Functional interactions between post-translationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

The paper identifies a methyltransferase responsible for S-methylcysteine modification in MCR and shows that interactions between post-translational modifications affect enzyme function and thermal stability.

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

The paper identifies thioglycine modification in McrA, a key enzyme in methane metabolism, and shows its role in protein stability rather than catalysis, with implications for evolutionary origins.