CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies
G. Gulden, B. Sert, T. Teymur, Y. Ay, N. N. Tiryaki, E. Ovali, N. Tarhan, C. Tastan
This study shows that using Phytohemagglutinin (PHA) to activate CAR-T cells increases their proliferation, memory T cell populations, and anti-cancer efficacy compared to aCD3/aCD28 activation.
Vaccines · Jan 31, 2023Peer-reviewedCancer Biology