Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
L. Torrente, N. Prieto, A. Falzone, D. A. Boothman, E. B. Haura, G. M. DeNicola
This study shows that NRF2/KEAP1 mutations confer resistance to β-lapachone by enhancing ROS detoxification, and that inhibiting SOD1 or the thioredoxin system can overcome this resistance.
bioRxiv · Nov 25, 2019Cancer Biology