The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc
M. Dudek, H. Morris, N. Rogers, D. R. Pathiranage, D. Chan, K. E. Kadler, J. A. Hoyland, Q.-J. Meng
This study shows that BMAL1, a circadian clock factor, regulates ECM homeostasis and cell fate in the intervertebral disc, with its loss causing ECM dysregulation and osteogenic differentiation.
bioRxiv · Feb 12, 2023Physiology