Author

K. E. Kadler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Pickard· 5 shared J. Chang· 5 shared R. Garva· 5 shared Y. Lu· 5 shared Q.-J. Meng· 3 shared V. Mallikarjun· 3 shared B. Calverley· 2 shared C. Lawless· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersCell Biology

A. Pickard

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Modelling collagen fibril self-assembly from extracellular medium in embryonic tendon

C. K. Revell, J. A. Herrera, C. Lawless, Y. Lu, K. E. Kadler, J. Chang, O. E. Jensen

The paper models collagen fibril self-assembly in embryonic mouse tendon, showing that fibrils form extracellularly through a phase-transition mechanism, supported by experimental data.

bioRxiv · Mar 13, 2023Biophysics

The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc

M. Dudek, H. Morris, N. Rogers, D. R. Pathiranage, D. Chan, K. E. Kadler, J. A. Hoyland, Q.-J. Meng

This study shows that BMAL1, a circadian clock factor, regulates ECM homeostasis and cell fate in the intervertebral disc, with its loss causing ECM dysregulation and osteogenic differentiation.

bioRxiv · Feb 12, 2023Physiology

Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

C.-Y. C. Yeung, R. Garva, A. Pickard, Y. Lu, V. Mallikarjun, J. Swift, S. H. Taylor, J. Rai, D. R. Eyre, M. Chaturvedi, Y. Itoh, Q.-J. Meng, C. Mauch, P. Zigrino, K. E. Kadler

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

bioRxiv · Apr 1, 2022Cell Biology

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

J. CHANG, A. PICKARD, J. A. Herrera, S. O'Keefe, M. Hartshorn, R. GARVA, A. Hoyle, L. Dingle, C. Zeltz, J. Wong, A. Reid, R. V. Venkateswaran, Y. Lu, P. Caswell, S. High, , K. E. KADLER

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

bioRxiv · Mar 25, 2021Cell Biology

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

A. Pickard, B. C. Calverley, J. Chang, R. Garva, Y. Lu, K. E. Kadler

This study identifies 35 FDA-approved drugs that reduce SARS-CoV-2 replication in human cells, including amodiaquine and vitamin D3.

bioRxiv · Jan 31, 2021Immunology

Circadian time series proteomics reveals daily dynamics in cartilage physiology

M. Dudek, C. Angelucci, J. P. Ruckshanthi, P. Wang, V. Mallikarjun, C. Lawless, K. E. Kadler, J. A. Hoyland, S. R. Lamande, J. F. Bateman, Q.-J. Meng

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.

bioRxiv · May 31, 2019Physiology

Circadian control of the secretory pathway is a central mechanism in tissue homeostasis

J. Chang, R. Garva, A. Pickard, C.-Y. C. Yeung, V. Mallikarjun, J. Swift, D. F. Holmes, B. Calverley, Y. Lu, A. Adamson, H. Raymond-Hayling, O. Jensen, T. Shearer, Q. J. Meng, K. E. Kadler

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.

bioRxiv · Apr 7, 2019Cell Biology

Preservation of circadian rhythms by the protein folding chaperone, BiP

A. Pickard, J. Chang, N. Alachkar, B. Calverley, R. Garva, P. Arvan, Q. J. Meng, K. E. Kadler

The paper shows that BiP and chemical chaperones strengthen circadian rhythms in fibroblasts under ER stress and prevent ER stress in tendon by regulating collagen synthesis.

bioRxiv · Oct 4, 2018Cell Biology