The IRE1 Inhibitor KIRA6 Curtails The Inflammatory Trait Of Immunogenic Anticancer Treatments By Targeting HSP60 Independent Of IRE1
N. Rufo, D. Korovesis, S. van Eygen, R. Derua, A. D. Garg, F. Finotello, M. Vara Perez, J. Rozanc, M. Dewaele, P. A. de Witte, L. Alexopoulos, S. Janssens, L. Sinkkonen, T. Sauter, S. H. L. Verhelst, P. Agostinis
The paper shows KIRA6 reduces inflammation from immunogenic cancer treatments by targeting HSP60, not through IRE1 inhibition.
bioRxiv · Dec 24, 2020 · PreprintCancer Biology