S. Janssens

High-throughput phenotyping reveals multiple drought responses of wild and cultivated Phaseolinae beans

This study evaluates drought tolerance in 151 Phaseolinae bean accessions using high-throughput phenotyping, revealing distinct trait responses and correlations with climate variables.

Type 1 immunity enables neonatal thymic ILC1 production

The paper shows type 1 immunity drives thymic production and peripheral migration of ILC1s in neonates.

Activation of goblet cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

This study identifies AGR2 as a chaperone that regulates IRE1β activity in goblet cells by preventing its dimerization and endonuclease activity.

Global Phylogeny of the Brassicaceae Provides Important Insights into Gene Discordance

This paper presents a comprehensive Brassicaceae phylogeny, identifies cytonuclear discordance due to hybridization, and proposes new tribes, providing a tool for biodiversity and plant biology studies.

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.

This study shows that IRE1 RNase activity in tumor-associated dendritic cells regulates antitumor immunity, with XBP1s deficiency leading to increased tumor growth and impaired T cell responses.

Distinct cDC subsets co-operate in CD40 agonist response while suppressive microenvironments and lack of antigens subvert efficacy

This study identifies cDC subsets that cooperate in CD40 agonist response and shows that suppressive microenvironments and antigen scarcity limit its efficacy in cancer.

Effects of forest disturbance and regeneration on tree species composition and traits in DR Congo

This study assesses the effects of forest disturbance and regeneration on tree species composition and traits in DR Congo, finding reduced tree density and altered species composition in disturbed and regrowth forests compared to undisturbed old-growth forests.

Genetic diversity of the pathogenic banana Fusarium wilt in northern Viet Nam

The paper identifies the genetic diversity of Fusarium wilt pathogens in northern Viet Nam, finding Foc Race 1 as the dominant strain, with a potential new pathogen in the FFSC.

The IRE1 Inhibitor KIRA6 Curtails The Inflammatory Trait Of Immunogenic Anticancer Treatments By Targeting HSP60 Independent Of IRE1

The paper shows KIRA6 reduces inflammation from immunogenic cancer treatments by targeting HSP60, not through IRE1 inhibition.

Multiple origins of insular woodiness on the Canary Islands are consistent with palaeoclimatic aridification

The paper estimates the timing of woodiness origin in Canary Island plant lineages and links it to historical aridification events.

Phylogenomic analysis clarifies the evolutionary origin of Coffea arabica L.

The paper determines the evolutionary origin of Coffea arabica by analyzing genetic distances and reconstructing a phylogenetic tree, identifying C. canephora and C. eugenioides as its progenitors.

Pre-adaptation to climate change through topography-driven evolution of traits and their plasticity

This study shows that plant populations from different topographical settings evolve distinct trait plasticity and fitness responses to drought, with high-altitude populations being pre-adapted to climate change.

A large-scale species level dated angiosperm phylogeny for evolutionary and ecological analyses

The paper constructs a large-scale dated angiosperm phylogeny using plastid genes and fossils, enabling broad evolutionary and ecological analyses.

Single-cell RNA-seq analysis reveals the crucial role of Collagen Triplex Helix Repeat Containing 1 (CTHRC1) cardiac fibroblasts for ventricular remodeling after myocardial infarction

This study identifies a pro-fibrotic fibroblast subpopulation in mice after myocardial infarction, showing CTHRC1's role in ventricular remodeling and cardiac function.

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.

Phylogenomics within the Anthonotha clade (Detarioideae, Leguminosae) reveals a high diversity in floral trait shifts and a general trend towards organ number reduction

This study uses phylogenomic data to analyze floral trait evolution in the Anthonotha clade, revealing high diversity in floral trait shifts and a trend towards organ number reduction.

Mutations in nucleoporin NUP88 cause lethal neuromuscular disorder

This study identifies biallelic NUP88 mutations as a cause of lethal fetal akinesia deformation sequence (FADS) and shows their effects on neuromuscular development in zebrafish and human cells.

Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

This study shows that mutations in ATL3 cause aberrant ER membrane tethering, disrupting ER network organization and contributing to sensory neuropathy.