Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate
V. Tiwari, R. Tandon, N. V. Sankaranarayanan, J. C. Beer, E. K. Kohlmeir, M. Swanson-Mungerson, U. R. Desai
This study shows 3-O-sulfated heparan sulfate enhances SARS-CoV-2 spike protein-mediated cell fusion, which can be blocked by a synthetic small molecule.
bioRxiv · Oct 8, 2020 · PreprintBiochemistry