A homodimeric aptamer variant generated from ligand-guided selection activates T-cell receptor cluster of differentiation three complex
L. Freage, D. Jamal, N. Williamns, P. Mallikaratchy
This paper develops a dimeric DNA aptamer that activates TCR-CD3 complex in T-cells, showing potential as an immunotherapeutic with tunable pharmacokinetics.
bioRxiv · May 18, 2020Biochemistry