MCT4 and CD147 co-localize with MMP14 in invadopodia and autolysosomes and collectively stimulate breast cancer cell invasion by increasing extracellular matrix degradation
S. Meng, E. E. Sorensen, M. Ponniah, J. Thorlacius-Ussing, R. Crouigneau, M. T. Borre, N. Willumsen, M. Flinck, S. F. Pedersen
This study shows MCT4 and CD147 work together in breast cancer cells to enhance invasion by boosting ECM degradation through interactions with MMP14.
bioRxiv · Sep 3, 2023 · PreprintCancer Biology