Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
S. E. Sandler, R. I. Horne, S. Rocchetti, R. Novak, N.-S. Hsu, M. C. Cruz, Z. F. Brotzakis, R. C. Gregory, S. Chia, G. J. L. Bernardes, U. F. Keyser, M. Vendruscolo
This paper introduces a single-molecule method using solid-state nanopores and DNA barcoding to detect and characterize misfolded protein oligomers, demonstrating its application to α-synuclein in Parkinson's disease.
bioRxiv · Aug 9, 2023 · PreprintBiophysics