Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension
Jason Shirian, Alexandra Hockla, Justyna Trynda, Matt Coban, Naama Rotenberg, Laura M. Strik, Aylin Alasonyalılar Demirer, Matt L. Pawlush, John Alton Copland, Evette S. Radisky, Julia M. Shifman
This study extends the plasma half-life of N-TIMP2 by appending a PATylated tail, showing improved therapeutic potential in mice.
Biomolecules · Sep 20, 2024Peer-reviewedBiochemistry