Induction of pluripotent oncogenic stem cells from mouse fibroblasts
Snehal Shabrish, Leimarembi Devi Naorem, Shubham Mohanty, Rohit Kumar, Relestina Simon Lopes, Nabila Akhtar, Naveen Kumar Khare, Ruchi Joshi, Rajashree Sawant, Gorantla Venkata Raghuram, Vishalkumar Jadhav, Sushma Shinde, Pratik Chandrani, Indraneel Mittra
The paper shows that cell-free chromatin particles from cancer patients can transform mouse fibroblasts into cancer stem cells capable of forming tumors and expressing germline markers.
Scientific Reports · Jul 15, 2025Peer-reviewedCancer Biology