Loss of cell-identity DNA methylation tracks division history, not DNA damage
Naor Sagy, Nadav Benedek, Daniel Zvi Bar
The paper tests whether DNA damage drives aging by analyzing cell-identity DNA methylation changes in human fibroblasts and finds that division history, not DNA damage, correlates with loss of identity information.
bioRxiv · Nov 3, 2026 · PreprintMolecular Biology