Daniel Zvi Bar

Loss of cell-identity DNA methylation tracks division history, not DNA damage

The paper tests whether DNA damage drives aging by analyzing cell-identity DNA methylation changes in human fibroblasts and finds that division history, not DNA damage, correlates with loss of identity information.

Colon-Specific Epigenetic Clocks from Minimal Features Reveal Disease-Driven Aging

The paper develops colon-specific epigenetic clocks using minimal CpG sites to predict age and reveal disease-driven aging in the colon.

A fusion Cell-Permeable C16orf74 Peptide Selectively Disrupts Calcineurin-NFAT Interaction and Inhibits T-cell Activation Without Cytotoxicity

The paper develops cell-permeable C16orf74 peptides that disrupt Calcineurin-NFAT interaction, inhibit T-cell activation, and show minimal cytotoxicity compared to Cyclosporine A.

Reversible and Causal Epigenetic Information Loss in Liver Aging and Disease

This paper shows that liver-specific methylation sites regress toward a pan-tissue average during aging and disease, and this loss can be partially reversed by fasting.

Epigenetic information loss is a common feature of multiple diseases and aging

The paper shows that epigenetic information loss, characterized by degradation of tissue-unique methylation patterns, occurs in multiple diseases and aging.

Detecting Protein-DNA Binding in Single Molecules using Antibody Guided Methylation

The paper introduces a method to detect protein-DNA binding in single molecules using antibody-guided methylation, generating identifiable methylation patterns near binding sites.

Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression

The paper identifies kidney-specific methylation patterns that correlate with kidney function and show changes during disease progression.

The hidden secrets of the dental calculus: Calibration of a mass spectrometry protocol for dental calculus protein analysis

This paper calibrates a mass spectrometry protocol for extracting and analyzing proteins from dental calculus, showing that acetic acid, crushing, and sonication maximize yield while acetone precipitation enhances protein identification.

Biotinylation by antibody recognition - A novel method for proximity labeling

This paper introduces a proximity labeling method using antibodies to detect protein interactions in fixed cells and tissues, revealing tissue-specific variations in the nuclear envelope and altered interactions under stress.