Naor Sagy

The paper tests whether DNA damage drives aging by analyzing cell-identity DNA methylation changes in human fibroblasts and finds that division history, not DNA damage, correlates with loss of identity information.

The paper develops colon-specific epigenetic clocks using minimal CpG sites to predict age and reveal disease-driven aging in the colon.

This paper shows that liver-specific methylation sites regress toward a pan-tissue average during aging and disease, and this loss can be partially reversed by fasting.

The paper shows that epigenetic information loss, characterized by degradation of tissue-unique methylation patterns, occurs in multiple diseases and aging.

The paper introduces a method to detect protein-DNA binding in single molecules using antibody-guided methylation, generating identifiable methylation patterns near binding sites.

The paper identifies kidney-specific methylation patterns that correlate with kidney function and show changes during disease progression.

The paper studies how embryoid bodies integrate environmental and biochemical signals to determine symmetry breaking through the positioning of the Brachyury onset locus.