Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Anika Gupta, Norma M. Morella, Dmitry A. Sutormin, Naisi Li, Karl D. Gaisser, Alexander Robertson, Yaroslav Ispolatov, Georg Seelig, Neelendu Dey, Anna Kuchina
The paper profiles single-cell transcriptomes of Bacteroides fragilis infected with a phage, revealing combinatorial phase-variable expression of defense systems that enable super-resistant cells to avoid phage infection without mutations.
bioRxiv · Jan 13, 2025 · PreprintSystems Biology