Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons
Parshva Mehta, Namrata Tiwari, Cristina Smith, Shanwei Shen, Taggert Barton, Aron H. Lichtman, Liya Y. Qiao
This study identifies TrkB.T1-mediated spinal neuroinflammation as a mechanism for colitis-induced referred somatic pain, with distinct pathways for mechanical and thermal hypersensitivity.
bioRxiv · Jul 28, 2026 · PreprintNeuroscience