Aron H. Lichtman

Liposomal DAGLβ Inhibitor Shows Substantial Antinociceptive Potency Mediated by AMPK in a Neuropathic Pain Mouse Models

The paper demonstrates that liposomal DAGLβ inhibitor KT109 shows significantly higher antinociceptive potency in neuropathic pain models, mediated by AMPK activation.

Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons

This study identifies TrkB.T1-mediated spinal neuroinflammation as a mechanism for colitis-induced referred somatic pain, with distinct pathways for mechanical and thermal hypersensitivity.

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

This study evaluates the effects of ZCZ011, a CB1R PAM, on behavior and the endocannabinoid system in HIV-1 Tat transgenic mice, showing sex- and genotype-dependent outcomes.