Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts
Huixun Du, Jacob Rose, Joanna Bons, Li Guo, Taylor R. Valentino, Fei Wu, Jordan B. Burton, Nathan Basisty, Max Manwaring-Mueller, Priya Makhijani, Nan Chen, Veronica Chang, Shawn Winer, Judith Campisi, David Furman, , Daniel A. Winer
This study shows that substrate stiffness influences doxorubicin-induced senescence and secretory profiles in human pulmonary fibroblasts, with collagen enrichment observed in high-stiffness conditions.
GeroScience · Jan 18, 2025Peer-reviewedCell Biology