Jordan B. Burton

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

This paper develops a proteomic workflow using data-independent acquisitions to analyze APOE3-derived neurons and microglia, identifying cell type-specific markers and pathways.

This study identifies aging-associated proteomic and lipid signatures in exosomes from senescent cells and human plasma, revealing shared biomarkers and pathways linked to senescence and tissue damage.

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

This study identifies age-related dysregulation of the splicing machinery in older AML patients through proteomic analysis, highlighting potential targets for age-specific therapies.

The paper identifies stromal protein profiles in breast cancer subtypes using proteomic analysis of FFPE tissues, revealing significant ECM and immune-related changes, particularly in metaplastic breast cancer.

This study shows that substrate stiffness influences doxorubicin-induced senescence and secretory profiles in human pulmonary fibroblasts, with collagen enrichment observed in high-stiffness conditions.