FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASES
Dmitry M. Hushpulian, Navneet Ammal Kaidery, Priyanka Soni, Andrey A. Poloznikov, A. A. Zakhariants, A. V. Razumovskaya, M. O. Silkina, Vladimir I. Tishkov, Eliot H. Kazakov, Abraham M. Brown, Irina N. Gaisina, Young‐Hoon Ahn, Sergey Viktorovich Kazakov, Nancy A. Krucher, Sudarshana M. Sharma, , Bobby Thomas
This paper identifies HPPE as a bipartite Nrf2 activator that overcomes feedback regulation by inhibiting Bach1, showing potential for treating age-related neurodegeneration.
Redox Biology · Jul 30, 2025Peer-reviewedBiochemistry