Sex differences in the genetic architecture of clinical quantitative traits in the electronic health record
Freida Blostein, Banabithi Bose, Andrew Hill, Ky’Era V. Actkins, Allison M. Lake, Naomi Freilich, Peter Straub, Maria Niarchou, Barbara E. Stranger, Lea Karatheodoris Davis
The paper identifies sex-specific genetic loci for clinical traits using EHR data, finding that differential effect magnitudes, not opposing effects, dominate sex-specific genetic architecture.
medRxiv · Sep 7, 2026 · PreprintGenetic & Genomic Medicine