Allison M. Lake

The paper identifies sex-specific genetic loci for clinical traits using EHR data, finding that differential effect magnitudes, not opposing effects, dominate sex-specific genetic architecture.

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

The paper shows astrocytes have a translational response to neuronal activity, altering their proteome at synapses through BDNF and K+ signals.

The paper identifies a genetic variant in TMEM106B associated with increased neuronal proportion in neurodegenerative and cognitive normal cohorts, suggesting a role in neuronal protection.

The paper shows astrocytes perform local translation in their peripheral processes, identifies candidate transcripts, and links them to synaptic regulation.