AlphaFold reveals but sometimes distorts an organizational principle of protein folding
Madeleine F Clore, Joseph F. Thole, Suchetan Dontha, Pramesh Sharma, Naomi Greenberg, Marie‐Paule Strub, Mary R. Starich, Carolyn M. Ott, Davin R. Jensen, Brian F. Volkman, Matthew Coudron, Lauren L. Porter
The paper uses AlphaFold to identify gating residues that control conformational accessibility in proteins, finding that AlphaFold sometimes misapplies this principle.
bioRxiv · Jul 21, 2026 · PreprintBioinformatics