Joseph F. Thole

The paper uses AlphaFold to identify gating residues that control conformational accessibility in proteins, finding that AlphaFold sometimes misapplies this principle.

The paper evaluates AF-cluster's performance on metamorphic proteins and finds random sequence sampling outperforms it, suggesting ColabFold-based methods as a better alternative.

This study evaluates AlphaFold2's ability to predict fold-switching proteins and finds it has limited success in sampling multiple conformations and accurately assessing confidence metrics.

The paper identifies Parkinson's risk variants in a SNCA enhancer by analyzing open chromatin in mouse dopamine neurons and validates their function in zebrafish and mice.

The paper screens Hsa21 gene overexpression in zebrafish to study dosage-sensitive effects on early development and identify potential contributors to Down syndrome pathology.