The Virtual Lab: AI Agents Design New SARS-CoV-2 Nanobodies with Experimental Validation
Kyle Swanson, Wesley C. H. Wu, Nash L. Bulaong, John E. Pak, James Zou
Role-specialised LLM agents under an LLM principal investigator, with light human steering, assembled an ESM/AlphaFold-Multimer/Rosetta pipeline and designed 92 SARS-CoV-2 nanobodies; two bound recent variants better.
bioRxiv · Nov 11, 2024 · PreprintBioinformatics