Wesley C. H. Wu

The paper uses language modeling to create a comprehensive representation of protein biology, enabling structure prediction and discovery of high-affinity protein interactions.

Role-specialised LLM agents under an LLM principal investigator, with light human steering, assembled an ESM/AlphaFold-Multimer/Rosetta pipeline and designed 92 SARS-CoV-2 nanobodies; two bound recent variants better.

This paper describes a method to produce soluble recombinant human MOG in SHuffle bacteria without refolding, enabling B cell-dependent EAE studies.

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.

The paper identifies a SARS-CoV-2 N gene polymorphism that reduces RT-PCR assay sensitivity and emphasizes the need for multi-target testing.

MinorityReport identifies genetic variants between two genome alignments to detect causal mutations in drug resistance or genotype-phenotype relationships.