Automated high-throughput selection of DNA aptamers using a common optical next-generation sequencer
Alissa Drees, Christian Ahlers, Timothy Kehrer, Natascha Ehmke, Alice Frederike Rosa Grün, Charlotte Uetrecht, Zoya Ignatova, Udo Schumacher, Markus Fischer
This paper develops an automated high-throughput platform for DNA aptamer selection using an optical next-generation sequencer, achieving higher affinity aptamers in fewer rounds than conventional SELEX.
bioRxiv · Jun 24, 2024Biochemistry