Differential Control of HIV-1 Replication by IFN-α14 Compared to IFN-α2 Relates to Differences in the Modulation of Host Antiretroviral Restriction Factors
Saurav Saswat Rout, Madeline T.E. Stewart, Nathan B. Seidel, Ulf Dittmer, Kathrin Sutter, Kerry J. Lavender
This study identifies ISG15 and APOBEC3G as key effectors of IFN-14's enhanced antiviral activity against HIV-1 compared to IFN-2.
bioRxiv · Nov 1, 2025 · PreprintImmunology