Maintaining the methionine residues of the chaperone Spy in a reduced state is crucial for periplasmic proteostasis.
Laurent Loiseau, Nathan De Visch, Alexandra Vergnes, Jean Armengaud, Maxence S. Vincent, Benjamin Ezraty
This study shows that chlorite stress increases Spy production, and MsrPQ repairs oxidized Spy to maintain periplasmic protein homeostasis.
PLoS Biology · Sep 29, 2025Peer-reviewedMicrobiology