Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration
Xuehan Sun, Lidan Wu, Timothy C. Orr, Ashley Heck, Kimberly Young, Nathan Dunaway, Jose Ceja Navarro, Joseph Beechem, Miranda E. Orr
The paper uses single-cell spatial transcriptomics to analyze tau pathology in mouse brains, revealing cell-autonomous and non-autonomous effects of tau accumulation on gene expression and pathways.
bioRxiv · Nov 19, 2025 · PreprintNeuroscience