Timothy C. Orr

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohort

The paper identifies senescence-associated molecular states in ALS motor neurons, showing regional and pathological differences but shared senescence features across ALS subtypes.

Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration

The paper uses single-cell spatial transcriptomics to analyze tau pathology in mouse brains, revealing cell-autonomous and non-autonomous effects of tau accumulation on gene expression and pathways.

Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer's Neuropathology

The paper presents a spatial multi-omics workflow for Alzheimer's neuropathology, resolving spatially distinct molecular domains and establishing analytical guidelines.