Miranda E. Orr

The paper identifies senescence-associated molecular states in ALS motor neurons, showing regional and pathological differences but shared senescence features across ALS subtypes.

The paper uses single-cell spatial transcriptomics to analyze tau pathology in mouse brains, revealing cell-autonomous and non-autonomous effects of tau accumulation on gene expression and pathways.

The paper presents a spatial multi-omics workflow for Alzheimer's neuropathology, resolving spatially distinct molecular domains and establishing analytical guidelines.

HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.

This study shows that pathogenic tau accelerates transposable element activation in the aging mouse brain, particularly ERVs, suggesting a link between tauopathy and transposable element-induced neurotoxicity.

This study shows that tau protein aggregation leads to cellular senescence in the brain, contributing to neurodegeneration, and that senolytic treatment can reduce pathology and improve brain function in mouse models.