Environment-dependent epistasis shapes adaptation to fluctuating resources.
Ashlynn G Bruder, Nathan Fiedeldey, Sarah B. Worthan, Zeer Cen, Megan G. Behringer
This study shows how fluctuating environments shape genetic interactions in E. coli by selecting for mutations in transport genes that exhibit environment-dependent epistasis and improve fitness across feast and famine conditions.
bioRxiv · Aug 4, 2026 · PreprintEvolutionary Biology