Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineeredNicotiana benthamiana
Quentin M. Dudley, Seohyun Jo, Delia Ayled Serna Guerrero, Monika Chhetry, Mark A. Smedley, Wendy Harwood, Nathaniel H. Sherden, Sarah Ellen O'Connor, Lorenzo Caputi, Nicola J. Patron
The paper reconstitutes strictosidine biosynthesis in Nicotiana benthamiana by co-expressing 14 enzymes, with MLPL from Nepeta enhancing flux through the iridoid pathway.
Communications Biology · Sep 10, 2022Peer-reviewedSynthetic Biology