Author

Nathaniel Sin

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Arthur A MeloiD· 1 shared Daniel R. SouthworthiD· 1 shared Eric TseiD· 1 shared Jason E. GestwickiiD· 1 shared N. YaniD· 1 shared Wyatt C. PowelliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Arthur A MeloORCID

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1 paper

Recent·Most cited

Phosphorylation of S396 and S400 Promotes Tau Self-Assembly and Favors the Chronic Traumatic Encephalopathy (CTE) Protofilament Fold

Wyatt C. Powell, N. Yan, Eric Tse, Arthur A Melo, Nathaniel Sin, Daniel R. Southworth, Jason E. Gestwicki

The paper investigates how phosphorylation at specific sites affects tau self-assembly, finding that S396 and S400 phosphorylation promotes aggregation while T403 and S404 phosphorylation suppresses it, with pS400 forming a CTE protofilament structure.

bioRxiv · May 21, 2026 · PreprintBiochemistry