Translational Downregulation of 5' TOP mRNAs During T Cell Exhaustion
Erica S. Pledger, Navya Ambavaram, Lucas Ferguson, Jamie H. D. Cate
The paper identifies translational repression of 5' TOP mRNAs in exhausted human CD8+ T cells despite elevated mTOR activity.
bioRxiv · Dec 16, 2025 · PreprintMolecular Biology