CLONAL SELECTION SUPPORTED BY SINGLE CELL DNA SEQUENCING REVEALS HORMONAL ADAPTATION AND RESISTANCE IN LOCALLY ADVANCED BREAST CANCER DURING NEOADJUVANT AROMATASE INHIBITION
Denise G O'Mahony, Tom Lesluyes, Ina Skaara Brorson, Patrik Vernhoff, Ksenia Sokolova, Miriam R. R. Aure, Grethe Grenaker Alnæs, Rebecca Mae Hooen, Arvind Y.M. Sundaram, Chandra L. Theesfeld, Stephanie Beate Geisler, Torill Sauer, Nazli Bahrami, Rahul Parulkar, Andliena Tahiri, , Vessela Nedelcheva Kristensen
This study uses whole-exome sequencing and single-cell DNA sequencing to analyze subclonal evolution in breast cancer during aromatase inhibitor treatment, identifying resistance mechanisms and actionable targets.
bioRxiv · Sep 24, 2025 · PreprintCancer Biology