HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation
Yuan Yang, Maria Grazia Murrali, Sabrina Galvan, Yaqiang Wang, Christine Stephen, Neha Ajjampore, Xiaoyu Wang, Juli F. Feigon
The paper investigates how HEXIM1 autoinhibition is overcome by 7SK RNA binding to enable P-TEFb inactivation, revealing structural and functional mechanisms of 7SK RNP assembly.
Nature Communications · Jan 15, 2026Peer-reviewedBiophysics