The Dorsomedial Prefrontal Cortex Uses Reward Predictions to Regulate How Rewards Are Pursued
Briac Halbout, Collin Hutson, Neha Ramiah, Gabriela Arias, Nitya Naik, Kate M. Wassum, Sean B. Ostlund
The paper shows that the dorsomedial prefrontal cortex (dmPFC) uses reward predictions to regulate how rewards are pursued, with cues signaling imminent reward suppressing instrumental seeking and cues signaling sparse reward invigorating it.
bioRxiv · Sep 3, 2026 · PreprintNeuroscience