Inference of clonal hematopoiesis using the collective behaviour of DNA methylation states
Samuel Crofts, Caleb M. Grenko, Neil A. Robertson, Kristina Kirschner, Tamir Chandra
The paper develops COMET, a method to infer clonal hematopoiesis from bulk DNA methylation data, showing it accurately detects clonal expansion and replicates known genetic associations.
bioRxiv · Nov 18, 2025 · PreprintGenetics