Kristina Kirschner

The paper develops COMET, a method to infer clonal hematopoiesis from bulk DNA methylation data, showing it accurately detects clonal expansion and replicates known genetic associations.

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.

The paper investigates how mutation timing, fitness, and clonal structure influence the clinical progression of clonal hematopoiesis using longitudinal cohort data.

The paper identifies two neutrophil subtypes in cancer using single-cell RNA sequencing, showing their conservation across species and tumor types, and links them to immunosuppressive pathways.

The paper shows p57Kip2 limits HSC numbers by restricting SNS progenitor size and catecholamine secretion in the AGM region via β2-adrenergic signaling.

The paper shows that age-related clonal haemopoiesis is linked to accelerated epigenetic age.

The paper identifies Notch signalling as essential for secondary senescence, distinguishing it from primary senescence through molecular endpoints.

SC3 improves scRNA-seq clustering by integrating multiple methods, outperforming existing tools on twelve datasets and analyzing 44,808 cells.