Restoring Amyloid Clearance via Astrocytes: Z17 Is a Selective Inhibitor of CHI3L1 in Alzheimers Disease
Hossam Nada, Longfei Zhang, Baljit Kaur, Nelson García Vázquez, Moustafa Tarek Gabr
This paper identifies Z17 as a selective CHI3L1 inhibitor that restores astrocytic function and mitigates neuroinflammation in Alzheimer's disease.
bioRxiv · Dec 10, 2025 · PreprintNeuroscience