Programming the elongation of mammalian cell aggregates with synthetic gene circuits
Josquin Courte, Christian Chung, Naisargee Jain, Catcher C. Salazar, Neo Phuchane, Steffen Grosser, Calvin K. Lam, Leonardo Morsut
This paper designs and implements synthetic gene circuits to program axial elongation in mammalian cell aggregates by controlling proliferation, tissue fluidity, and cell-cell signaling.
bioRxiv · Dec 11, 2024 · PreprintSynthetic Biology