Calvin K. Lam

This study shows that CBFB::MYH11 is required for leukemia survival in spleen and peripheral blood but not in bone marrow, where it can be bypassed.

This paper shows PAMD-Ch17, a modified Plerixafor analog, kills T-ALL cells via mitochondrial dysfunction independent of CXCR4 inhibition.

The paper identifies PTBP1 as a RUNX1 interacting partner required for leukemia cell survival through metabolic gene regulation.

This paper designs and implements synthetic gene circuits to program axial elongation in mammalian cell aggregates by controlling proliferation, tissue fluidity, and cell-cell signaling.

The paper designs synthetic inhibitory circuits to study multicellular self-organization and shows they can generate patterned structures and morphological oscillations.

The paper designs and analyzes transcription factor-based amplifiers to improve temporal control in synthetic circuits, enhancing self-organization and tumor-killing capabilities of CAR T cells.