Leonardo Morsut

This paper introduces a novel reaction-diffusion architecture called JAPI for engineering self-organized patterns in mammalian cells, demonstrating its ability to generate spatial patterns with fewer parameters than classical diffusion-based systems.

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.

The paper demonstrates a novel protocol to generate motile cardiomyocyte aggregates from mouse embryonic stem cells, enhancing their contractility and motility for biobot development.

This paper designs and implements synthetic gene circuits to program axial elongation in mammalian cell aggregates by controlling proliferation, tissue fluidity, and cell-cell signaling.

This study defines axial nephron patterning in human kidney organoids by using synthetic Wnt-secreting organizers to mimic developmental signals and achieve in vivo-like polarity.

The paper develops synthetic Notch receptor-based material-to-cell signaling pathways to spatially control cellular phenotypes in multicellular constructs.

This study shows how cell density affects signal transduction in synthetic gene circuits, enabling spatial and temporal control of multicellular patterning.