Pretreatment with estrogen enhances the therapeutic efficacy of cardiac progenitor cells and improves cardiac recovery in a failing heart model
Dunya Aydos, Neslihan Basak, Yusuf Olğar, Kardelen Genc, Recep Uyar, Okan Ekim, Taras Sych, Zeynep Büşra Aksoy, Tugba Aktan Kosker, Erdinç Sezgin, Ceylan Verda Bitirim
This study shows that estrogen pretreatment of cardiac progenitor cells improves their engraftment and therapeutic efficacy in a failing heart model, enhancing cardiac recovery and reducing pathological remodeling.
bioRxiv · Jun 25, 2025 · PreprintMolecular Biology