A probabilistic view of protein stability, conformational specificity, and design
Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley Charles Bundy, Joshua L. Price, David Wingate, Dennis Della Corte
The paper defines protein stability and conformational specificity probabilistically and introduces BayesDesign, a sequence decoding algorithm that maximizes p(structure|seq) for protein design.
Scientific Reports · Sep 19, 2023Peer-reviewedBioinformatics